Introduction
Materials and methods
Construct weighted gene regulatory network of ICH
Collect chemical ingredients of DTT
Select potential active ingredients of DTT based on ICH models
Predicting targets of active ingredients
Node importance calculation method
Gene ontology and pathway analysis
Experimental validation
Materials
Cell Culture and oxygen–glucose deprivation (ogd) treatment
Cell viability assay
Statistical analysis
Results
Chemical analysis
Herb | Method | Component | Concentration | Ref |
---|---|---|---|---|
Glycyrrhiza uralensis Fisch. ex DC | HPLC | Glycyrrhizin | 98.01 mg/g | Chen et al., 2009 [21] |
Liquiritin | 102.63 mg/g | |||
Isoliquritigenin | 98.18 mg/g | |||
Zingiber officinale Roscoe | HPLC | 6-Gingerol | 16.62 mg/g | Zhang et al., 2009 [22] |
6-Shogaol | 4.92 mg/g | |||
Citrus reticulata Blanco | HPLC | Naringin | 24.87 mg/g | Liu et al., 2013 [23] |
Hesperidin | 2.19 mg/g | |||
Arisaema heterophyllum Blume | HPLC | Guanosine | 0.436 mg/g | Zhang et al., 2020 [24] |
Adenosine | 0.642 mg/g | |||
Chafertoside | 0.618 mg/g | |||
Isochafertoside | 0.517 mg/g | |||
Panax ginseng C.A.Mey | HPLC–MS | Rg1 | 0.205 mg/g | Shang et al., 2018 [25] |
Re | 0.175 mg/g | |||
Rf | 0.050 mg/g | |||
Rb1 | 0.112 mg/g | |||
Rb2 | 0.033 mg/g | |||
Rd | 0.016 mg/g | |||
Pinellia ternata (Thunb.) Makino | RP-HPLC | Uridine | 0.224 mg·g | Chen et al., 2013 [26] |
guanosine | 0.337 mg·g | |||
adenosine | 0.084 mg·g | |||
Poria cocos (Schw.) Wolf | HPLC | Dehydrotumonic acid | 0.34 mg/g | Peng et al., 2017 [27] |
dehydrofulic acid | 0.29 mg/g | |||
poriatic acid | 0.72 mg/g | |||
melinolic acid | 0.15 mg/g | |||
Citrus acida Pers | HPLC | Naringenin | 1.91 mg/g | Zhan et al., 2015 [28] |
Hesperetin | 1.37 mg/g | |||
Marmin | 1.52 mg/g | |||
6’,7’-Dihydroxy bergamot | 2.96 mg/g | |||
Citronella | 2.90 mg/g | |||
Orange peel | 2.18 mg/g | |||
Bambusa tuldoides Munro | HPLC | Flavonoids | 0.81 mg/mL | Li et al., 2017 [29] |
Select potential active ingredients
Herb | MOL_ID | molecule_name | ob | caco2 | drug-likeness |
---|---|---|---|---|---|
Fuling | MOL000273 | (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid | 30.93 | 0.01 | 0.81 |
Fuling | MOL000275 | trametenolic acid | 38.71 | 0.52 | 0.80 |
Fuling | MOL000276 | 7,9(11)-dehydropachymic acid | 35.11 | 0.03 | 0.81 |
Fuling | MOL000279 | Cerevisterol | 37.96 | 0.28 | 0.77 |
Fuling | MOL000280 | (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid | 31.07 | 0.05 | 0.82 |
Fuling | MOL000282 | ergosta-7,22E-dien-3beta-ol | 43.51 | 1.32 | 0.72 |
Fuling | MOL000283 | Ergosterol peroxide | 40.36 | 0.84 | 0.81 |
Fuling | MOL000285 | (2R)-2-[(5R,10S,13R,14R,16R,17R)-16-hydroxy-3-keto-4,4,10,13,14-pentamethyl-1,2,5,6,12,15,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-5-isopropyl-hex-5-enoic acid | 38.26 | 0.12 | 0.82 |
Fuling | MOL000287 | 3beta-Hydroxy-24-methylene-8-lanostene-21-oic acid | 38.70 | 0.61 | 0.81 |
Fuling | MOL000289 | pachymic acid | 33.63 | 0.10 | 0.81 |
Fuling | MOL000290 | Poricoic acid A | 30.61 | -0.14 | 0.76 |
Fuling | MOL000291 | Poricoic acid B | 30.52 | -0.08 | 0.75 |
Fuling | MOL000292 | poricoic acid C | 38.15 | 0.32 | 0.75 |
Fuling | MOL000296 | hederagenin | 36.91 | 1.32 | 0.75 |
Fuling | MOL000300 | dehydroeburicoic acid | 44.17 | 0.38 | 0.83 |
Renshen | MOL000358 | beta-sitosterol | 36.91 | 1.32 | 0.75 |
Renshen | MOL000422 | kaempferol | 41.88 | 0.26 | 0.24 |
Renshen | MOL000449 | Stigmasterol | 43.83 | 1.44 | 0.76 |
Renshen | MOL000749 | Linoleic | 41.90 | 1.23 | 0.14 |
Renshen | MOL000787 | Fumarine | 59.26 | 0.56 | 0.83 |
Renshen | MOL001641 | METHYL LINOLEATE | 41.93 | 1.44 | 0.17 |
Renshen | MOL002879 | Diop | 43.59 | 0.79 | 0.39 |
Renshen | MOL003648 | Inermin | 65.83 | 0.91 | 0.54 |
Renshen | MOL004492 | Chrysanthemaxanthin | 38.72 | 0.51 | 0.58 |
Renshen | MOL005308 | Aposiopolamine | 66.65 | 0.66 | 0.22 |
Renshen | MOL005314 | Celabenzine | 101.88 | 0.77 | 0.49 |
Renshen | MOL005317 | Deoxyharringtonine | 39.27 | 0.19 | 0.81 |
Renshen | MOL005320 | arachidonate | 45.57 | 1.27 | 0.20 |
Renshen | MOL005321 | Frutinone A | 65.90 | 0.89 | 0.34 |
Renshen | MOL005348 | Ginsenoside-Rh4_qt | 31.11 | 0.50 | 0.78 |
Renshen | MOL005356 | Girinimbin | 61.22 | 1.72 | 0.31 |
Renshen | MOL005357 | Gomisin B | 31.99 | 0.60 | 0.83 |
Renshen | MOL005360 | malkangunin | 57.71 | 0.22 | 0.63 |
Renshen | MOL005366 | Malvic acid | 30.99 | 1.22 | 0.15 |
Renshen | MOL005376 | Panaxadiol | 33.09 | 0.82 | 0.79 |
Renshen | MOL005384 | suchilactone | 57.52 | 0.82 | 0.56 |
Renshen | MOL005396 | cis-Widdrol alpha-epoxide | 69.04 | 1.07 | 0.15 |
Renshen | MOL005399 | alexandrin_qt | 36.91 | 1.30 | 0.75 |
Renshen | MOL005401 | ginsenoside Rg5_qt | 39.56 | 0.88 | 0.79 |
Juhong | MOL000358 | beta-sitosterol | 36.91 | 1.32 | 0.75 |
Juhong | MOL001040 | (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one | 42.36 | 0.38 | 0.21 |
Juhong | MOL001798 | neohesperidin_qt | 71.17 | 0.26 | 0.27 |
Juhong | MOL001942 | isoimperatorin | 45.46 | 0.97 | 0.23 |
Juhong | MOL004328 | naringenin | 59.29 | 0.28 | 0.21 |
Juhong | MOL005849 | didymin | 38.55 | 0.60 | 0.24 |
Juhong | MOL013331 | Isomeranzin | 42.78 | 0.69 | 0.15 |
Juhong | MOL013332 | Pranferol | 38.29 | 0.54 | 0.25 |
Juhong | MOL013352 | Obacunone | 43.29 | 0.01 | 0.77 |
Tiannanxing | MOL000131 | EIC | 41.90 | 1.16 | 0.14 |
Tiannanxing | MOL000358 | beta-sitosterol | 36.91 | 1.32 | 0.75 |
Tiannanxing | MOL000359 | sitosterol | 36.91 | 1.32 | 0.75 |
Tiannanxing | MOL000432 | linolenic acid | 45.01 | 1.21 | 0.15 |
Tiannanxing | MOL000449 | Stigmasterol | 43.83 | 1.44 | 0.76 |
Tiannanxing | MOL000953 | CLR | 37.87 | 1.43 | 0.68 |
Tiannanxing | MOL001510 | 24-epicampesterol | 37.58 | 1.43 | 0.71 |
Tiannanxing | MOL001641 | METHYL LINOLEATE | 41.93 | 1.44 | 0.17 |
Tiannanxing | MOL002203 | Exceparl M-OL | 31.90 | 1.39 | 0.16 |
Tiannanxing | MOL010925 | Isooleic acid | 33.13 | 1.15 | 0.14 |
Tiannanxing | MOL013131 | 12,15-Octadecadienoic acid, methyl ester | 41.93 | 1.46 | 0.17 |
Tiannanxing | MOL013144 | Methyl (6E,9E)-6,9-octadecadienoate | 41.93 | 1.44 | 0.17 |
Tiannanxing | MOL013145 | Methyl-7,10-octadecadienoate | 41.93 | 1.43 | 0.17 |
Tiannanxing | MOL013146 | 8,11,14-Docosatrienoic acid, methyl ester | 43.23 | 1.53 | 0.30 |
Tiannanxing | MOL013156 | [(2R)-2-[[[(2R)-2-(benzoylamino)-3-phenylpropanoyl]amino]methyl]-3-phenylpropyl] acetate | 38.88 | 0.35 | 0.56 |
Banxia | MOL000131 | EIC | 41.90 | 1.16 | 0.14 |
Banxia | MOL000358 | beta-sitosterol | 36.91 | 1.32 | 0.75 |
Banxia | MOL000432 | linolenic acid | 45.01 | 1.21 | 0.15 |
Banxia | MOL000449 | Stigmasterol | 43.83 | 1.44 | 0.76 |
Banxia | MOL000519 | coniferin | 31.11 | 0.42 | 0.32 |
Banxia | MOL000675 | oleic acid | 33.13 | 1.17 | 0.14 |
Banxia | MOL001755 | 24-Ethylcholest-4-en-3-one | 36.08 | 1.46 | 0.76 |
Banxia | MOL002495 | 6-shogaol | 31.00 | 1.07 | 0.14 |
Banxia | MOL002670 | Cavidine | 35.64 | 1.08 | 0.81 |
Banxia | MOL002714 | baicalein | 33.52 | 0.63 | 0.21 |
Banxia | MOL003578 | Cycloartenol | 38.69 | 1.53 | 0.78 |
Banxia | MOL005030 | gondoic acid | 30.70 | 1.20 | 0.20 |
Banxia | MOL006936 | 10,13-eicosadienoic | 39.99 | 1.22 | 0.20 |
Banxia | MOL006937 | 12,13-epoxy-9-hydroxynonadeca-7,10-dienoic acid | 42.15 | 0.18 | 0.24 |
Banxia | MOL006944 | 8-Octadecenoic acid | 33.13 | 1.15 | 0.14 |
Banxia | MOL006956 | cyclo-(leu-tyr) | 111.16 | 0.16 | 0.15 |
Banxia | MOL006957 | (3S,6S)-3-(benzyl)-6-(4-hydroxybenzyl)piperazine-2,5-quinone | 46.89 | 0.41 | 0.27 |
Zhishi | MOL000006 | luteolin | 36.16 | 0.19 | 0.25 |
Zhishi | MOL000131 | EIC | 41.90 | 1.16 | 0.14 |
Zhishi | MOL001798 | neohesperidin_qt | 71.17 | 0.26 | 0.27 |
Zhishi | MOL001803 | Sinensetin | 50.56 | 1.12 | 0.45 |
Zhishi | MOL001941 | Ammidin | 34.55 | 1.13 | 0.22 |
Zhishi | MOL002914 | Eriodyctiol (flavanone) | 41.35 | 0.05 | 0.24 |
Zhishi | MOL004328 | naringenin | 59.29 | 0.28 | 0.21 |
Zhishi | MOL005100 | 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one | 47.74 | 0.28 | 0.27 |
Zhishi | MOL005828 | nobiletin | 61.67 | 1.05 | 0.52 |
Zhishi | MOL005849 | didymin | 38.55 | 0.60 | 0.24 |
Zhishi | MOL007879 | Tetramethoxyluteolin | 43.68 | 0.96 | 0.37 |
Zhishi | MOL009053 | 4-[(2S,3R)-5-[(E)-3-hydroxyprop-1-enyl]-7-methoxy-3-methylol-2,3-dihydrobenzofuran-2-yl]-2-methoxy-phenol | 50.76 | 0.03 | 0.39 |
Zhishi | MOL013277 | Isosinensetin | 51.15 | 1.16 | 0.44 |
Zhishi | MOL013279 | 5,7,4'-Trimethylapigenin | 39.83 | 1.01 | 0.30 |
Zhishi | MOL013352 | Obacunone | 43.29 | 0.01 | 0.77 |
Zhishi | MOL013430 | Prangenin | 43.60 | 0.80 | 0.29 |
Zhishi | MOL013433 | prangenin hydrate | 72.63 | 0.14 | 0.29 |
Zhishi | MOL013435 | poncimarin | 63.62 | 0.66 | 0.35 |
Zhishi | MOL013436 | isoponcimarin | 63.28 | 0.50 | 0.31 |
Zhishi | MOL013437 | 6-Methoxy aurapten | 31.24 | 1.01 | 0.30 |
Zhishi | MOL013443 | isolimonic acid | 48.86 | 0.43 | 0.18 |
Zhishi | MOL013445 | naringenin-4'-glucoside-7-rutinoside_qt | 30.61 | 0.33 | 0.16 |
Gancao | MOL000098 | quercetin | 46.43 | 0.05 | 0.28 |
Gancao | MOL000211 | Mairin | 55.38 | 0.73 | 0.78 |
Gancao | MOL000239 | Jaranol | 50.83 | 0.61 | 0.29 |
Gancao | MOL000354 | isorhamnetin | 49.60 | 0.31 | 0.31 |
Gancao | MOL000359 | sitosterol | 36.91 | 1.32 | 0.75 |
Gancao | MOL000392 | formononetin | 69.67 | 0.78 | 0.21 |
Gancao | MOL000417 | Calycosin | 47.75 | 0.52 | 0.24 |
Gancao | MOL000422 | kaempferol | 41.88 | 0.26 | 0.24 |
Gancao | MOL000497 | licochalcone a | 40.79 | 0.82 | 0.29 |
Gancao | MOL000500 | Vestitol | 74.66 | 0.86 | 0.21 |
Gancao | MOL001484 | Inermine | 75.18 | 0.89 | 0.54 |
Gancao | MOL001789 | isoliquiritigenin | 85.32 | 0.44 | 0.15 |
Gancao | MOL001792 | DFV | 32.76 | 0.51 | 0.18 |
Gancao | MOL002311 | Glycyrol | 90.78 | 0.71 | 0.67 |
Gancao | MOL002565 | Medicarpin | 49.22 | 1.00 | 0.34 |
Gancao | MOL002844 | Pinocembrin | 64.72 | 0.61 | 0.18 |
Gancao | MOL003656 | Lupiwighteone | 51.64 | 0.68 | 0.37 |
Gancao | MOL003896 | 7-Methoxy-2-methyl isoflavone | 42.56 | 1.16 | 0.20 |
Gancao | MOL004328 | naringenin | 59.29 | 0.28 | 0.21 |
Gancao | MOL004805 | (2S)-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8,8-dimethyl-2,3-dihydropyrano[2,3-f]chromen-4-one | 31.79 | 1.00 | 0.72 |
Gancao | MOL004806 | euchrenone | 30.29 | 1.09 | 0.57 |
Gancao | MOL004808 | glyasperin B | 65.22 | 0.47 | 0.44 |
Gancao | MOL004810 | glyasperin F | 75.84 | 0.43 | 0.54 |
Gancao | MOL004811 | Glyasperin C | 45.56 | 0.71 | 0.40 |
Gancao | MOL004814 | Isotrifoliol | 31.94 | 0.53 | 0.42 |
Gancao | MOL004815 | (E)-1-(2,4-dihydroxyphenyl)-3-(2,2-dimethylchromen-6-yl)prop-2-en-1-one | 39.62 | 0.66 | 0.35 |
Gancao | MOL004820 | kanzonols W | 50.48 | 0.63 | 0.52 |
Gancao | MOL004824 | (2S)-6-(2,4-dihydroxyphenyl)-2-(2-hydroxypropan-2-yl)-4-methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one | 60.25 | 0.00 | 0.63 |
Gancao | MOL004827 | Semilicoisoflavone B | 48.78 | 0.45 | 0.55 |
Gancao | MOL004828 | Glepidotin A | 44.72 | 0.79 | 0.35 |
Gancao | MOL004829 | Glepidotin B | 64.46 | 0.46 | 0.34 |
Gancao | MOL004833 | Phaseolinisoflavan | 32.01 | 1.01 | 0.45 |
Gancao | MOL004835 | Glypallichalcone | 61.60 | 0.76 | 0.19 |
Gancao | MOL004836 | echinatin | 66.58 | 0.38 | 0.17 |
Gancao | MOL004838 | 8-(6-hydroxy-2-benzofuranyl)-2,2-dimethyl-5-chromenol | 58.44 | 1.00 | 0.38 |
Gancao | MOL004841 | Licochalcone B | 76.76 | 0.47 | 0.19 |
Gancao | MOL004848 | licochalcone G | 49.25 | 0.64 | 0.32 |
Gancao | MOL004849 | 3-(2,4-dihydroxyphenyl)-8-(1,1-dimethylprop-2-enyl)-7-hydroxy-5-methoxy-coumarin | 59.62 | 0.40 | 0.43 |
Gancao | MOL004855 | Licoricone | 63.58 | 0.53 | 0.47 |
Gancao | MOL004856 | Gancaonin A | 51.08 | 0.80 | 0.40 |
Gancao | MOL004857 | Gancaonin B | 48.79 | 0.58 | 0.45 |
Gancao | MOL004863 | 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-(3-methylbut-2-enyl)chromone | 66.37 | 0.52 | 0.41 |
Gancao | MOL004864 | 5,7-dihydroxy-3-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromone | 30.49 | 0.90 | 0.41 |
Gancao | MOL004866 | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromone | 44.15 | 0.48 | 0.41 |
Gancao | MOL004879 | Glycyrin | 52.61 | 0.59 | 0.47 |
Gancao | MOL004882 | Licocoumarone | 33.21 | 0.84 | 0.36 |
Gancao | MOL004883 | Licoisoflavone | 41.61 | 0.37 | 0.42 |
Gancao | MOL004884 | Licoisoflavone B | 38.93 | 0.46 | 0.55 |
Gancao | MOL004885 | licoisoflavanone | 52.47 | 0.39 | 0.54 |
Gancao | MOL004891 | shinpterocarpin | 80.30 | 1.10 | 0.73 |
Gancao | MOL004898 | (E)-3-[3,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one | 46.27 | 0.41 | 0.31 |
Gancao | MOL004904 | licopyranocoumarin | 80.36 | 0.13 | 0.65 |
Gancao | MOL004905 | 3,22-Dihydroxy-11-oxo-delta(12)-oleanene-27-alpha-methoxycarbonyl-29-oic acid | 34.32 | -0.06 | 0.55 |
Gancao | MOL004907 | Glyzaglabrin | 61.07 | 0.34 | 0.35 |
Gancao | MOL004908 | Glabridin | 53.25 | 0.97 | 0.47 |
Gancao | MOL004910 | Glabranin | 52.90 | 0.97 | 0.31 |
Gancao | MOL004911 | Glabrene | 46.27 | 0.99 | 0.44 |
Gancao | MOL004912 | Glabrone | 52.51 | 0.59 | 0.50 |
Gancao | MOL004913 | 1,3-dihydroxy-9-methoxy-6-benzofurano[3,2-c]chromenone | 48.14 | 0.48 | 0.43 |
Gancao | MOL004914 | 1,3-dihydroxy-8,9-dimethoxy-6-benzofurano[3,2-c]chromenone | 62.90 | 0.40 | 0.53 |
Gancao | MOL004915 | Eurycarpin A | 43.28 | 0.43 | 0.37 |
Gancao | MOL004935 | Sigmoidin-B | 34.88 | 0.42 | 0.41 |
Gancao | MOL004941 | (2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one | 71.12 | 0.41 | 0.18 |
Gancao | MOL004945 | (2S)-7-hydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chroman-4-one | 36.57 | 0.72 | 0.32 |
Gancao | MOL004948 | Isoglycyrol | 44.70 | 0.91 | 0.84 |
Gancao | MOL004949 | Isolicoflavonol | 45.17 | 0.54 | 0.42 |
Gancao | MOL004957 | HMO | 38.37 | 0.79 | 0.21 |
Gancao | MOL004959 | 1-Methoxyphaseollidin | 69.98 | 1.01 | 0.64 |
Gancao | MOL004961 | Quercetin der | 46.45 | 0.39 | 0.33 |
Gancao | MOL004966 | 3'-Hydroxy-4'-O-Methylglabridin | 43.71 | 1.00 | 0.57 |
Gancao | MOL004974 | 3'-Methoxyglabridin | 46.16 | 0.94 | 0.57 |
Gancao | MOL004978 | 2-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]-5-methoxyphenol | 36.21 | 1.12 | 0.52 |
Gancao | MOL004980 | Inflacoumarin A | 39.71 | 0.73 | 0.33 |
Gancao | MOL004985 | icos-5-enoic acid | 30.70 | 1.22 | 0.20 |
Gancao | MOL004988 | Kanzonol F | 32.47 | 1.18 | 0.89 |
Gancao | MOL004989 | 6-prenylated eriodictyol | 39.22 | 0.40 | 0.41 |
Gancao | MOL004990 | 7,2',4'-trihydroxy-5-methoxy-3-arylcoumarin | 83.71 | 0.24 | 0.27 |
Gancao | MOL004991 | 7-Acetoxy-2-methylisoflavone | 38.92 | 0.74 | 0.26 |
Gancao | MOL004993 | 8-prenylated eriodictyol | 53.79 | 0.43 | 0.40 |
Gancao | MOL004996 | gadelaidic acid | 30.70 | 1.20 | 0.20 |
Gancao | MOL005000 | Gancaonin G | 60.44 | 0.78 | 0.39 |
Gancao | MOL005001 | Gancaonin H | 50.10 | 0.60 | 0.78 |
Gancao | MOL005003 | Licoagrocarpin | 58.81 | 1.23 | 0.58 |
Gancao | MOL005007 | Glyasperins M | 72.67 | 0.49 | 0.59 |
Gancao | MOL005008 | Glycyrrhiza flavonol A | 41.28 | -0.09 | 0.60 |
Gancao | MOL005012 | Licoagroisoflavone | 57.28 | 0.71 | 0.49 |
Gancao | MOL005016 | Odoratin | 49.95 | 0.42 | 0.30 |
Gancao | MOL005017 | Phaseol | 78.77 | 0.76 | 0.58 |
Gancao | MOL005018 | Xambioona | 54.85 | 1.09 | 0.87 |
Gancao | MOL005020 | dehydroglyasperins C | 53.82 | 0.68 | 0.37 |
Shengjiang | MOL000358 | beta-sitosterol | 36.91 | 1.32 | 0.75 |
Shengjiang | MOL002467 | 6-gingerol | 35.64 | 0.54 | 0.16 |
Shengjiang | MOL002495 | 6-shogaol | 31.00 | 1.07 | 0.14 |
Shengjiang | MOL006129 | 6-methylgingediacetate2 | 48.73 | 0.55 | 0.32 |
Construct the weighted gene regulatory network of ICH
Common ingredients of Chinese herbal medicines in DTT
ingredients | Herbs |
---|---|
6-shogaol | Pinellia ternata (Thunb.) Makino; Zingiber officinale Roscoe |
β-sitosterol | Pinellia ternata (Thunb.) Makino; Zingiber officinale Roscoe; Citrus reticulata Blanco; Panax ginseng C.A.Mey |
didymin | Citrus acida Pers; Citrus reticulata Blanco |
EIC | Pinellia ternata (Thunb.) Makino; Citrus reticulata Blanco; Arisaema heterophyllum Blume |
kaempferol | Glycyrrhiza uralensis Fisch. ex DC.; Panax ginseng C.A.Mey |
linolenic acid | Pinellia ternata (Thunb.) Makino; Arisaema heterophyllum Blume |
methyl linoleate | Arisaema heterophyllum Blume; Panax ginseng C.A.Mey.(Renshen) |
naringenin | Citrus reticulata Blanco; Citrus reticulata Blanco (Juhong); Glycyrrhiza uralensis Fisch. ex DC |
neohesperidin_qt | Citrus acida Pers; Citrus reticulata Blanco |
Obacunone | Citrus acida Pers; Citrus reticulata Blanco |
sitosterol | Arisaema heterophyllum Blume; Glycyrrhiza uralensis Fisch. ex DC |
Stigmasterol | Pinellia ternata (Thunb.) Makino; Arisaema heterophyllum Blume; Panax ginseng C.A.Mey |